Journal article
A neural mediator of human anxiety sensitivity
BJ Harrison, MA Fullana, C Soriano-Mas, E Via, J Pujol, I Martínez-Zalacaín, D Tinoco-Gonzalez, CG Davey, M López-Solà, V Pérez Sola, JM Menchón, N Cardoner
Human Brain Mapping | Published : 2015
DOI: 10.1002/hbm.22889
Abstract
Advances in the neuroscientific understanding of bodily autonomic awareness, or interoception, have led to the hypothesis that human trait anxiety sensitivity (AS)-the fear of bodily autonomic arousal-is primarily mediated by the anterior insular cortex. Despite broad appeal, few experimental studies have comprehensively addressed this hypothesis. We recruited 55 individuals exhibiting a range of AS and assessed them with functional magnetic resonance imaging (fMRI) during aversive fear conditioning. For each participant, three primary measures of interest were derived: a trait Anxiety Sensitivity Index score; an in-scanner rating of elevated bodily anxiety sensations during fear conditionin..
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Grants
Awarded by Instituto de Salud, Carlos III, Gobierno de Espana Project Grants
Awarded by LIIRA Program Grant
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC
Awarded by Instituto de Salud, Carlos III, Gobierno de Espana 'Miguel Servet' contract
Funding Acknowledgements
Contract grant sponsor: Instituto de Salud, Carlos III, Gobierno de Espana Project Grants; Contract grant number: PI12/0136 to NC and PI12/00273 to MF; Contract grant sponsor: LIIRA Program Grant; Contract grant number: WS717052 to NC; Contract grant sponsor: National Health and Medical Research Council of Australia (NHMRC) Project Grant; Contract grant number: 1025619 to BJH; Contract grant sponsor: NHMRC Clinical Career Development Fellowship; Contract grant number: 628509 to BJH; Contract grant sponsor: Instituto de Salud, Carlos III, Gobierno de Espana 'Miguel Servet' contract; Contract grant number: CP10/00604 to CSM